To profile IIS, run the profiler from Windows Start menu as administrator (privileges are needed to re-start IIS service):
Alternatively, change the profiler shortcut properties to always run the profiler as administrator:
When the profiler starts, choose corresponding item on the Welcome screen:
The dialog window will appear.
Choose profiling options, then press Profile to re-start IIS service with the profiler.
The profiler will automatically connect to the profiled application as soon as the application receives first request, e.g. as soon as you open its page in your browser.